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Hyperinsulinism — Novel Genes, Drugs and Guidelines

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Add to Calendar Hyperinsulinism — Novel Genes, Drugs and Guidelines 4/13/2023 8:00:00 AM 4/14/2023 5:00:00 PM America/New_York For More Details: https://chop.cloud-cme.com/course/courseoverview?EID=3486 Description: This two-day international symposium will review exciting developments in the field of hyperinsulinism, including novel genetic causes, new care guidelines and promising investigational therapies. The symposium is intended to enhance the knowledge and practice of endocrinologists, neonatologists, surgeons, pathologists, radiologists, geneticists and nurses as well as basic scientists interested in islet ... CHOP false MM/DD/YYYY


Date & Location
Thursday, April 13, 2023, 8:00 AM - Friday, April 14, 2023, 5:00 PM, CHOP, Philadelphia, PA

Overview
This two-day international symposium will review exciting developments in the field of hyperinsulinism, including novel genetic causes, new care guidelines and promising investigational therapies. The symposium is intended to enhance the knowledge and practice of endocrinologists, neonatologists, surgeons, pathologists, radiologists, geneticists and nurses as well as basic scientists interested in islet cell biology. The symposium faculty, leaders in the field of hyperinsulinism, will present over 20 plenary lectures on the biology, genetics and clinical aspects of hyperinsulinism. Participants will have the opportunity to engage with the faculty through several expert panels and breakout sessions.

Objectives
  1. Review the pathophysiology of hyperinsulinism and novel insights into islet cell function
  2. Discuss genetic etiologies of hyperinsulinism, including recently identified genes, and understand the role of genetic testing in management
  3. Review optimal short-term and long-term management of individuals with hyperinsulinism, including new clinical care guidelines

Registration
The conference will be at Children’s Hospital of Philadelphia. The registration fee is $350 for physicians and $250 for trainees and other healthcare professionals and includes continental breakfast, breaks, lunch, parking and syllabus material.

Accreditation
The Children's Hospital of Philadelphia is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education to physicians.

Credits
AMA PRA Category 1 Credits™ (11.50 hours), Non-Physician AMA PRA Category 1 Credits™ Attendance (includes PA, RT, RDMS) (11.50 hours)

A block of rooms has been reserved at reduced rates at The Study, located just a few blocks from Children’s Hospital. The group overnight rate is $229 single and double occupancy plus a 16.25 percent room tax. Participants are required to make their own hotel reservations by calling The Study directly at 215-387-1400. Please mention the name of the conference when making your reservation. The special room rate will be available until Sunday, March 12, 2023. After that date, reservations will be accepted on a space and rate availability basis.



Mitigation of Relevant Financial Relationships


Children's Hospital of Philadelphia adheres to the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education. Any individuals in a position to control the content of a CE activity, including faculty, planners, reviewers or others are required to disclose all relevant financial relationships with ineligible entities (commercial interests). All relevant conflicts of interest have been mitigated prior to the commencement of the activity.

Member Information
Role in activity
Nature of Relationship(s) / Name of Ineligible Company(s)
Diva De Leon, MD
Children's Hospital of Philadelphia
Co-Director, Faculty
Consulting Fee-Hanmi|Consulting Fee-Crinetics Pharmaceuticals, Inc|Consulting Fee-Eiger|Consulting Fee-Zealand Pharma|Consulting Fee-Heptares|Grant or research support-Crinetics (Relationship has ended)|Grant or research support-Twist Biopharma|Independent Contractor (included contracted research)-Hanmi|Independent Contractor (included contracted research)-Zealand Pharma|Independent Contractor (included contracted research)-Ultragenyx
Katherine Lord, MD
Children's Hospital of Philadelphia
Co-Director, Faculty
Nothing to disclose
Scott Adzick, MD, MMM, FACS, FAAP
Director, Center for Fetal Diagnosis and Treatment Surgeon-in-Chief, Department of Surgery
Children's Hospital of Philadelphia
Faculty
Nothing to disclose
Indi Banerjee, MD
Faculty
Nothing to disclose
Tricia Bhatti, MD
Children's Hospital of Philadelphia
Faculty
Nothing to disclose
Kara Boodhansingh
The Children's Hospital of Philadelphia
Faculty
Linda Boyajian, CRNP
CRNP
CHOP
Faculty
Liesje Carney
CHOP
Faculty
Lauren Cherry, RD
CHOP
Faculty
Nothing to disclose
Sherri Cohen, MD
Children's Hospital of Philadelphia
Faculty
Nothing to disclose
Antonia Dastamani, PhD
Great Ormond Street Hospital for Children, London, UK
Faculty
Nothing to disclose
Assmaa ElSheikh
OHSU
Faculty
Nothing to disclose
Jordan Evans, BSN
RN
CHOP
Faculty
Sophie Foss, PhD
CHOP
Faculty
Nothing to disclose
Arupa Ganguly,, PhD
Faculty
Nothing to disclose
Henrike Hoermann, MD
University Hospital Duesseldorf
Faculty
Nothing to disclose
Christine Juliana, PhD
Children's Hospital of Philadelphia
Faculty
Nothing to disclose
Jennifer Kalish, MD, PhD
Children's Hospital of Philadelphia
Faculty
Nothing to disclose
Arianna Maiorana, MD, PhD
Ospedale Pediatrico Bambino Gesù
Italy
Faculty
Asim Maqbool, MD
MD
CHOP
Faculty
Nothing to disclose
Thomas Meissner, MD

Faculty
Other: invitation to ESPE Meetin 2022, Rome-Novo Nordisk (Relationship has ended)|Honoraria-Merck and Company, Inc. (Relationship has ended)|Other: clinical study-Zealand
Maria Melikyan, MD, PhD
Yerevan state Medical University
Armenia
Faculty
Nothing to disclose
Klaus Mohnike
Otto-von-Guericke-Universität
Germany
Faculty
Membership on Advisory Committees or Review Panels, Board Membership, etc.-QED|Honoraria-Biomarin
Timo Otonkoski, MD, PhD
University of Helsinki, Finland
Faculty
Nothing to disclose
Faculty Photos
Elizabeth Rosenfeld, MD
Children's Hospital of Philadelphia
Faculty
Independent Contractor (included contracted research)-Rhythm Pharmaceuticals
Show-Ling Shyng, PhD
Oregon Health and Science University
Faculty
Nothing to disclose
Winnie Sigal, MD
Children's Hospital of Philadelphia
Faculty
Nothing to disclose
Charles Stanley, MD
MD
Faculty
Membership on Advisory Committees or Review Panels, Board Membership, etc.-Janssen|Membership on Advisory Committees or Review Panels, Board Membership, etc.-Zealand
Lisa States, MD
Children's Hospital of Philadelphia
Faculty
Nothing to disclose
Nicole Stewart
Registered Nurse
CHOP
Faculty
Paul Thornton, MD
Cook Children's Medical Center
Faculty
Grant or research support-Ascendis (Relationship has ended)|Grant or research support-Novo Nordisk |Grant or research support-Pfizer, Inc.|Consulting Fee-zealand|Grant or research support-Spruce|Consulting Fee-Spruce|Grant or research support-Opko
Radha Venkatesan, PhD
Madras Diabetes Research Foundation India
India
Faculty
Nothing to disclose
Chris Worth, MD
Royal Manchester Children's Hospital
United Kingdom
Faculty
Heather McKnight, CRNP
CRNP
Children's Hospital of Philadelphia
Faculty, Nurse Planner
Nothing to disclose

Thursday, April 13, 2023
Welcome and Introduction
8:00AM - 8:10AM
Diva De Leon, MD
From Idiopathic Hypoglycemia to Hyperinsulinism: A Historical Overview
8:10AM - 8:30AM
Charles Stanley, MD
Diazoxide-responsive Hyperinsulinism
8:30AM - 9:00AM
Elizabeth Rosenfeld, MD
Diazoxide-unresponsive Hyperinsulinism
9:00AM - 9:30AM
Diva De Leon, MD
Syndromic Hyperinsulinism
9:30AM - 10:00AM
Jennifer Kalish, MD, PhD
Break and Exhibits
10:00AM - 10:20AM
When an Insulin Level isn’t Enough: Approach to Diagnosis
10:20AM - 10:40AM
Katherine Lord, MD
Genetic Testing
10:40AM - 11:10AM
Arupa Ganguly,, PhD
Histologic Diagnosis in Hyperinsulinism
11:10AM - 11:30AM
Tricia Bhatti, MD
Expert Panel Q&A: Etiology & Diagnosis
11:30AM - 12:00PM
Luncheon
12:00PM - 12:45PM
Poster Session
12:45PM - 1:20PM
Approach to Management of Congenital Hyperinsulinism
1:20PM - 1:50PM
Katherine Lord, MD
18F-DOPA PET Imaging of Focal Hyperinsulinism
1:50PM - 2:10PM
Lisa States, MD
Surgery for Hyperinsulinism
2:10PM - 2:30PM
Scott Adzick, MD, MMM, FACS, FAAP
Hyperinsulinism Guidelines
2:30PM - 2:50PM
Paul Thornton, MD
Expert Panel Q&A: Management
2:50PM - 3:10PM
Break and Exhibits
3:10PM - 3:30PM
Congenital Hyperinsulinism: Descriptive Analysis of 151 Patients from An Italian Cohort
3:30PM - 3:45PM
Arianna Maiorana, MD, PhD
Hyperinsulinism Associated with Non-coding HK1 Mutations
3:45PM - 4:00PM
Kara Boodhansingh
Investigational Therapeutics 1
4:00PM - 4:20PM
Klaus Mohnike
Investigational Therapeutics 2
4:20PM - 4:45PM
Antonia Dastamani, PhD
Adjourn for the Day
4:45PM - 4:50PM
Friday, April 14, 2023
Islet Phenotype in Hyperinsulinism
8:00AM - 8:20AM
Diva De Leon, MD
KATP Channels
8:20AM - 8:40AM
Show-Ling Shyng, PhD
Stem Cell-based Models in Congenital Hyperinsulinism
8:40AM - 9:00AM
Timo Otonkoski, MD, PhD
The Voltage-gated K+ Channel Kv7.1 is Important for the Regulation of Insulin Secretion in Normal and Hyperinsulinemic Islets
9:00AM - 9:15AM
Christine Juliana, PhD
Identification of a New KATP Channel Pharmaco-chaperone from Cryo-EM Structure-based Virtual Screening
9:15AM - 9:30AM
Assmaa ElSheikh
Increased Catecholamines Link Fetal Stress or Growth Restriction and Neonatal Hyperinsulinemic Hypoglycemia: A Prospective Cohort Study
9:30AM - 9:45AM
Henrike Hoermann, MD
Universal Newborn Screening for Hyperinsulinism. Is it Time Yet?
9:45AM - 10:00AM
Diva De Leon, MD
Break and Exhibits
10:00AM - 10:20AM
Glucose Monitoring: Glucometers and Continuous Glucose Monitoring
10:20AM - 10:40AM
Indi Banerjee, MD
Management of the Child with Persistent Hypoglycemia after Pancreatectomy
10:40AM - 11:00AM
Winnie Sigal, MD
Post-pancreatectomy Diabetes
11:00AM - 11:20AM
Thomas Meissner, MD
Luncheon
11:20AM - 12:00PM
Poster Session
12:00PM - 12:30PM
Exocrine Insufficiency Following Pancreatectomy
12:30PM - 12:50PM
Asim Maqbool, MD
Feeding Issues in Congenital Hyperinsulinism
12:50PM - 1:10PM
Sherri Cohen, MD
Neurodevelopmental Outcomes
1:10PM - 1:30PM
Sophie Foss, PhD
Breakout Sessions — Q&A with the Experts
1:30PM - 2:30PM
Break and Exhibits
2:30PM - 2:45PM
Molecular Characterization and Genotype-phenotype Correlation of Congenital Hyperinsulinism in India
2:45PM - 3:00PM
Radha Venkatesan, PhD
A Yearlong Nationwide Trial of CGM for Patients with Hyperinsulinism: Outcomes, Trends and Family Experiences
3:00PM - 3:15PM
Chris Worth, MD
Adjourn
3:15PM - 3:20PM


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