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Topics in Hyperinsulinism

  • Overview
  • Register
  • Faculty
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  • Brochure
Add to Calendar Topics in Hyperinsulinism 10/2/2026 8:00:00 AM 10/3/2026 3:30:00 PM America/New_York For More Details: https://chop.cloud-cme.com/course/courseoverview?EID=15888 Description: This 2-day symposium will provide comprehensive education on the diagnosis and management of children with hyperinsulinism as well as review exciting advances in the field. The first day will feature lectures on all aspects of hyperinsulinism care and interactive sessions with world-renowned hyperinsulinism experts. The second day offers two tracks: 1) clinically focused activities with simulations, cas... HUB for Clinical Collaboration false MM/DD/YYYY


Date & Location
Friday, October 2, 2026, 8:00 AM - Saturday, October 3, 2026, 3:30 PM, HUB for Clinical Collaboration, Philadelphia, PA

Target Audience
Specialties - Neonatology, Nursing, Nursing - Advanced Practice, Pediatric Endocrinology, Diabetes and Metabolism, Pediatrics

Overview

This 2-day symposium will provide comprehensive education on the diagnosis and management of children with hyperinsulinism as well as review exciting advances in the field. The first day will feature lectures on all aspects of hyperinsulinism care and interactive sessions with world-renowned hyperinsulinism experts. The second day offers two tracks: 1) clinically focused activities with simulations, cases, and additional lectures on hyperinsulinism management or 2) research-focused activities with presentations on the latest scientific advances in beta cell biology, genetics, and drug development. The symposium is intended for endocrinologists, neonatologists, surgeons, radiologists, pathologists, and nurses, as well as other providers caring for these complex patients.


Objectives
  1. Discuss the known genetic etiologies of hyperinsulinism and their implications for clinical care and response to therapy.
  2. Employ effective strategies to rapidly diagnose hyperinsulinism and initiate treatment.
  3. Understand the optimal immediate and long-term management of children with hyperinsulinism to ensure the best outcomes.
  4. Review recent research advances in beta cell biology, genetics, and drug development for hyperinsulinism.

Accreditation

In support of improving patient care, Children’s Hospital of Philadelphia is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.


Credits
AMA PRA Category 1 Credits™ (12.50 hours), ANCC NCPD Contact Hours (12.50 hours), Non-Physician AMA PRA Category 1 Credits™ Attendance (includes PA, RT, RDMS) (12.50 hours)

Mitigation of Relevant Financial Relationships

Children's Hospital of Philadelphia adheres to the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education. Any individuals in a position to control the content of a CE activity, including faculty, planners, reviewers or others are required to disclose all relevant financial relationships with ineligible entities (commercial interests). All relevant conflicts of interest have been mitigated prior to the commencement of the activity.

Member Information
Role in activity
Nature of Relationship(s) / Name of Ineligible Company(s)
Lauren Mitteer, MEd, CCRP
Clinical Research Coordinator
Children's Hospital of Philadelphia
Activity Coordinator
Nothing to disclose
Katherine Lord, MD
Children's Hospital of Philadelphia
Co-Director, Faculty
Nothing to disclose
Diva De Leon, MD
Chief, Division of Endocrinology and Diabetes
Children's Hospital of Philadelphia
Course Director, Faculty
Consulting Fee-Rezolute|Grant or research support-Rezolute|Consulting Fee-Rhythm Pharmaceuticals|Grant or research support-Rhythm Pharmaceuticals|Consulting Fee-Confo Therapeutics|Consulting Fee-Ligand Pharamceuticals|Grant or research support-Moderna|Consulting Fee-Fortress Biotech|Consulting Fee-Zealand Pharma|Grant or research support-Hanmi|Grant or research support-Zealand Pharma|Grant or research support-Ultragenyx|Consulting Fee-Ultragenyx|Consulting Fee-AmideBio
Scott Adzick, MD, MMM, FACS, FAAP
Director, Center for Fetal Diagnosis and Treatment Surgeon-in-Chief, Department of Surgery
Children's Hospital of Philadelphia
Faculty
Nothing to disclose
Emilyn Alejandro, PhD
University of Minnesota
Faculty
Nothing to disclose
Ana Maria M Arbelaez, MD
Washington University in St. Louis
Faculty
Nothing to disclose
Tricia Bhatti, MD
Children's Hospital of Philadelphia
Faculty
Nothing to disclose
Liesje Carney, RD CSP LDN
CHOP
Faculty
Nothing to disclose
Sherri Cohen, MD
Children's Hospital of Philadelphia
Faculty
Nothing to disclose
Sophie Foss, PhD
Neuropsychologist
CHOP
Faculty
Nothing to disclose
Arupa Ganguly, PhD
Dr
University Of Pennsylvania
Faculty
Nothing to disclose
Jennifer Kalish, MD, PhD
Children's Hospital of Philadelphia
Faculty
Nothing to disclose
Karla Leavens, MD, PhD, Physician
CHOP
Faculty
Nothing to disclose
Asim Maqbool, MD
MD
CHOP
Faculty
Nothing to disclose
Colin G Nichols Nichols, PhD
Dr.
438442
Faculty
Nothing to disclose
Faculty Photos
Elizabeth Rosenfeld, MD
Children's Hospital of Philadelphia
Faculty
Nothing to disclose
Show-Ling Shyng, PhD
Professor
Oregon Health & Science University
Faculty
Nothing to disclose
Winnie Sigal, MD
Children's Hospital of Philadelphia
Faculty
Nothing to disclose
Lisa States, MD
Professyof Clinical Rady
Children's Hospital of Philadelphia
Faculty
Nothing to disclose
Paul S Thornton, MD
Division Chief Endocrinology and Diabetes
Cook Children's Medical Center
Faculty
Grant or research support-Ascendis|Grant or research support-Novo Nordisk (Relationship has ended)|Grant or research support-Pfizer, Inc.|Consulting Fee-zealand|Grant or research support-Spruce|Consulting Fee-Spruce|Grant or research support-Opko (Relationship has ended)|Consulting Fee-Neurocrine|Grant or research support-Lumos
Jordan Evans, BSN
RN
CHOP
Faculty, Other Planning Committee Member
Nothing to disclose
Heather McKnight, CRNP
CRNP
Children's Hospital of Philadelphia
Faculty, Other Planning Committee Member
Nothing to disclose
Victoria Sanders, MSGC
Children's Hospital of Philadelphia
Faculty, Other Planning Committee Member
Nothing to disclose
Kara E. Boodhansingh, PhD
Division of Endocrinology and Diabetes, The Children’s Hospital of Philadelphia Congenital Hyperinsulinism Center
Other Planning Committee Member
MOLLY CANNON, MSN
CHOP
Other Planning Committee Member
Nothing to disclose
Briana Carvalho, BA
Clinical Research Coordinator
CHOP
Other Planning Committee Member
Nothing to disclose
Christine Juliana, PhD
Children's Hospital of Philadelphia
Other Planning Committee Member
Nothing to disclose
Nicole Stewart, BSN
Registered Nurse
CHOP
Other Planning Committee Member
Nothing to disclose
Emily Wilkinson, MSN
CHOP
Other Planning Committee Member
Nothing to disclose

Friday, October 2, 2026
Welcome and Introduction
8:00AM - 8:15AM
Diva De Leon, MD

Perinatal Stress-Induced Hyperinsulinism
8:15AM - 8:30AM
Winnie Sigal, MD

Congenital Hyperinsulinism Part 1: KATP Hyperinsulinism
8:30AM - 9:00AM
Diva De Leon, MD

Congenital Hyperinsulinism Part 2: GDH, GCK, HK1 and Others
9:00AM - 9:30AM
Elizabeth Rosenfeld, MD

Syndromic Hyperinsulinism
9:30AM - 10:00AM
Jennifer Kalish, MD, PhD

Break
10:00AM - 10:15AM

Diagnosis of Hyperinsulinism
10:15AM - 10:40AM
Winnie Sigal, MD

Molecular Diagnosis of Hyperinsulinism
10:40AM - 11:05AM
Arupa Ganguly, PhD

Q&A with the Experts
11:05AM - 11:35AM

Overview of Hyperinsulinism Management
11:35AM - 11:50AM
Katherine Lord, MD

Lunch
11:50AM - 1:10PM

Glucose Monitoring
1:10PM - 1:30PM
Paul S Thornton, MD

Medical Management of Hyperinsulinism
1:30PM - 1:50PM
Katherine Lord, MD

18F DOPA PET Imaging of Focal Hyperinsulinism
1:50PM - 2:10PM
Lisa States, MD

Surgery for Hyperinsulinism
2:10PM - 2:30PM
Scott Adzick, MD, MMM, FACS, FAAP

Histology of Hyperinsulinism
2:30PM - 2:50PM
Tricia Bhatti, MD

Q&A with the Experts
2:50PM - 3:15PM

Break
3:15PM - 3:30PM

Post-Pancreatectomy Diabetes
3:30PM - 3:50PM
Paul S Thornton, MD

Exocrine Insufficiency
3:50PM - 4:10PM
Asim Maqbool, MD

Neurodevelopmental Outcomes
4:10PM - 4:30PM
Elizabeth Rosenfeld, MD

Expert Panel Q&A
4:30PM - 4:50PM

Wrap-up Day 1
4:50PM - 5:00PM

Saturday, October 3, 2026
CLINICAL TRACK--The Use of Fasting Tests in Hyperinsulinism
8:00AM - 8:20AM
Katherine Lord, MD

Genetic Testing Basics
8:20AM - 8:40AM
Victoria Sanders, MSGC

Research Track-Structural Basis of KATP Channels: Trafficking, Gating, and Rescue
8:30AM - 9:00AM
Show-Ling Shyng, PhD

Feeding Issues in Hyperinsulinism
8:40AM - 9:00AM
Sherri Cohen, MD

Nutrition for Children with Hyperinsulinism
9:00AM - 9:20AM
Liesje Carney, RD CSP LDN

Research Track-KATP Channels in Hyperinsulinism and Diabetes
9:00AM - 9:30AM
Colin G Nichols Nichols, PhD

Care of Children Post-Pancreatectomy
9:20AM - 9:40AM
Heather McKnight, CRNP

Research Track-Suppression of CAMKII-dependent Amplifying Pathway Underlies Impaired Insulin Secretion in Absence of Beta-cell KATP Channels
9:30AM - 9:45AM

Understanding Neurodevelopmental Screening
9:40AM - 10:00AM
Sophie Foss, PhD

Research Track-Rescue of KATP Channel Nonsense Mutations Using Anticodon-edited Transfer RNAs
9:45AM - 10:00AM

Break
10:00AM - 10:20AM

Research Track Break
10:00AM - 10:15AM

Research Track-Maternal/Pregnancy Effects on Beta-cell Development and Function
10:15AM - 10:45AM
Emilyn Alejandro, PhD

Simulation Sessions
10:20AM - 12:00PM

Research Track-The Alpha Cell in Hyperinsulinism: A Passive Bystander?
10:45AM - 11:00AM
Diva De Leon, MD

Research Track-Molecular Spectrum and Genotype–Phenotype Correlation of Congenital Hyperinsulinism in India
11:00AM - 11:15AM

Research Track-Congenital Hyperinsulinism: Clinical Course, Genetic Characteristics, and Management Outcome, Single Tertiary Center Experience
11:15AM - 11:30AM

Research Track-Misdiagnosis and Diagnostic Delays in Congenital Hyperinsulinism: Insights from the HI Global Registry
11:30AM - 11:45AM

Research Track-Accuracy of Continuous Glucose Monitoring in Neonates and Infants with Hypoglycemia in a Neonatal Intensive Care Unit
11:45AM - 12:00PM

Lunch
12:00PM - 1:20PM

Research Track- Lunch
12:00PM - 1:30PM

Clinical Track Breakout Session 3- ? Post-Pancreatectomy Care
1:20PM - 2:20PM
Heather McKnight, CRNP
Paul S Thornton, MD

Clinical Track Breakout Session1-Medical Management
1:20PM - 2:20PM
Winnie Sigal, MD
Katherine Lord, MD

Clinical Track Breakout Session2-Genetic Testing Interpretation
1:20PM - 2:20PM
Jennifer Kalish, MD, PhD
Victoria Sanders, MSGC

Clinical Track- Breakout Session 4-Neurodevelopment in Hyperinsulinism
1:20PM - 2:20PM
Elizabeth Rosenfeld, MD
Sophie Foss, PhD

Clinical Track- Breakout Session 5-Nutrition and Feeding Issues
1:20PM - 2:20PM
Liesje Carney, RD CSP LDN
Sherri Cohen, MD

Research Track-Brain and Physiologic Responses to Hypoglycemia: What Can We Learn from Studies in Diabetes?
1:30PM - 2:00PM
Ana Maria M Arbelaez, MD

Research Track-Utilization of cfDNA to Identify Low-level Mosaic Mutations in Congenital Hyperinsulinism
2:00PM - 2:15PM

Research Track-Umbilical Cord Glucose as a Potential Universal Screening Tool for Pathological Hyperinsulinism
2:15PM - 2:30PM

Challenging Cases in Hyperinsulinism
2:20PM - 3:00PM
Katherine Lord, MD

Research Track-Cell Replacement Therapy for Type 1 Diabetes: Is There a Future for Hyperinsulinism
2:30PM - 3:00PM
Karla Leavens, MD, PhD, Physician

The Future of Hyperinsulinism Care
3:00PM - 3:20PM
Diva De Leon, MD

Wrap-up
3:20PM - 3:30PM

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