Address:

The Children's Hospital of Philadelphia
3401 Civic Center Boulevard
8NW37, Division of Pediatric Cardiology

Philadelphia, PA 19104 United States

If you are not a U.S. citizen or holder of a permanent visa, please indicate the type of visa you have:

none (U.S. citizen)

Education:

1997

B.S.

University of Nebraska-Lincoln (Biochemistry)

2006

Ph.D.

Vanderbilt University School of Medicine (Cell and Developmental Biology and Philosophy)

2009

M.D.

Vanderbilt University of School of Medicine

Postgraduate Training and Fellowship Appointments:

2009-2011

Resident in General Pediatrics, The Children's Hospital of Philadelphia, Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

2011-2015

Fellow in Pediatric Cardiology, The Children's Hospital of Philadelphia, Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

2014-2017

Postdoctoral Fellow, Department of Medicine, Penn Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania

Faculty Appointments:

2009-2017

Instructor B of Pediatrics, The Children's Hospital of Philadelphia, Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

2017-present

Assistant Professor of Pediatrics, University of Pennsylvania School of Medicine

Hospital and/or Administrative Appointments:

2015-present

Attending, Children's Hospital of Philadelphia

2017-present

Assistant Program Director, Pediatric Cardiology T32 Training Grant, Children's Hospital of Philadelphia

Other Appointments:

2017-present

Member, Penn-CHOP Lung Biology Institute, The University of Pennsylvania

2017-present

Primary Faculty, Cardiovascular Institute, The University of Pennsylvania

Specialty Certification:

2012

American Board of Pediatrics

2018

American Board of Pediatrics-Cardiology

Licensure:

2009

Pennsylvania State Board of Medicine

Awards, Honors and Membership in Honorary Societies:

1997

Howard Hughes Undergraduate Summer Research Award, University of Nebraska-Lincoln

1998-2000

Predoctoral Cancer Research Training Award, National Cancer Institute

2001-2009

Microbes and Defense Academic Society, Vanderbilt University School of Medicine

2005

Genzyme Keystone Conference Scholarship, Keystone Conference on TGF-beta and disease

2009

Richard B. Johnston Jr. Award in Pediatrics, Vanderbilt University School of Medicine

2011

Research Day Poster Award Winner, Children's Hospital of Philadelphia

2013

Fellow's Award, 6th International Conference Neonatal and Childhood Pulmonary Vascular Disease

2014

Research Day Poster Award Winner, Children's Hospital of Philadelphia

2014

Finalist Presenter, The Neonatal Cardiopulmonary Biology Young Investigator's Forum

2015

Fellow Research Award, Pediatric Academic Society/Society for Pediatric Research

2015

Poster Award Winner, Gordon Conference on Lung Development, Injury, and Repair

2016-2019

Parker B. Francis Fellowship Program Awardee

2017

Smart Heart Award, Children's Heart Foundation (Pennsylvania Chapter)

2020-2023

Doris Duke Charitable Foundation Clinician Scientist Development Award

Memberships in Professional and Scientific Societies and Other Professional Activities:

   National:

2011-Present

American College of Cardiology

2018-Present

American Heart Association
(Member, Dev Basic Science Fellowship Review Committee)

2018-Present

American Thoracic Society

Editorial Positions:

2017-Present

Reviewer-Development

2018-Present

Reviewer-American Journal of Respiratory and Critical Care Medicine

2019-Present

Reviewer-Journal of Medical Genetics

2019-Present

Reviewer, European Respiratory Journal

2021-Present

Reviewer-American Journal of Physiology-Lung Cellular and Molecular Physiology

2021-present

Reviewer, Elife

Academic and Institutional Committees:

2016-Present

Member, Cardiac Center Strategic Planning (Maintaining Talent in the Cardiac Center Workgroup), Children's Hospital of Philadelphia

2016-Present

Member, Cardiac Center Strategic Planning (Research Workgroup), Children's Hospital of Philadelphia

2019-2020

Drug and Safety Monitoring Board, Baricitinib in Aicardi Goutieres Syndrome, Children's Hospital of Philadelphia

Major Academic and Clinical Teaching Responsibilities; Clinical Services:

2016-Present

"Pathway-targeted identification of stem cells in postnatal lung generation".  Invited seminar to Pediatric Critical Care Medicine Research Conference, CHOP

2017-Present

"Wnt-responsive progenitor cells in late lung alveolar generation".  Invited seminar to CHOP Cardiac Intensive Care Unit Research Conference at CHOP

2017-2019

Mentor, Josh Pankin, undergraduate medical student, BIO 399, University of Pennsylvania School of Medicine

2017

"Defining mechanisms of cardiopulmonary cell fate for pediatric pulmonary hypertension therapy", Penn CVI Fall Seminar series

2017

"Early lung progenitor cell commitment redefines alveolar epithelial ontogeny" Penn Stem Cell Club speaker series, Smilow TRC 9-146

2018-Present

"Dissecting developmental mechanisms of cell fate, tissue regeneration, and homeostasis in pulmonary hypertension", CHOP Pediatric Cardiology Research Lecture

2018-Present

"The developmental ontogeny, generation, and regeneration of the lung alveolus", CHOP Neonatology Research Seminar

2018-2019

Mentor, Post-doctoral fellow, Aravind Sivakumar PhD, The Children's Hospital of Philadelphia

2018-present

Scholarship Oversight Committee member for Jonathan Edwards, MD, fellow in Pediatric Cardiology, The Children's Hospital of Philadelphia

2019-Present

"Deciphering normal developmental lung cellular ontogeny relevant to pediatric PH", CHOP Division of Neonatology Research Seminar

2019-Present

Lecturer, "Lung Development and branching morphogenesis", University of Pennsylvania CAMB 511 Principles of Development

2019-Present

"Deciphering normal developmental lung cellular ontogeny relevant to pediatric PH", CHOP Division of Pulmonary Medicine Lecture

2019-present

Mentor for UPenn undergraduate, Sukhmani Kaur

2019-present

Mentor for UPenn undergraduate, Hongbo Wen

2019-present

Lecturer, Lung Physiology 1-3, CAMB 532 Human Physiology

2019-present

Mentor, Kwaku Quansah, UPenn PREP program

2020-Present

CHOP Pediatric Cardiology Lecture Series, "Using cardiopulmonary developmental paradigms to shape tissue regeneration and repair" January 13th, 2020.

2020-present

Co-mentor with Dr. Bill Gaynor for Maureen Peers De Nieuwburgh, Firmin van Brée of the Hoover Foundation for the University of Louvain Fellow

2021-Present

Interrogating Evolutionary Paradigms for Mammalian Pulmonary Vascular Development and Disease, Penn-CHOP Lung Biology Institute Spring 2021 Virtual Seminar Series

Lectures by Invitation:

Sep, 2014

"Wnt signaling specific cellular contribution and interactions during alveologenesis". The Neonatal Cardiopulmonary Biology Young Investigator's Forum, Chicago, IL

Apr, 2015

"Enhanced alveolar epithelial progenitor cell differentiation in Wnt signaling-responsive cells during alveologenesis".  Invited Speaker (SPR Fellow's Award) at the Pediatric Academic Society Annual Meeting, San Diego, CA

Nov, 2015

"Wnt signaling-responsive cells define an alveolar epithelial progenitor cell niche during alveologenesis", Vanderbilt University School of Medicine, Department of Pediatrics Research Conference, Nashville, TN

Sep, 2016

"Wnt-responsive progenitor cells in late lung development and regeneration". Child Health Research Career Development Award Annual Retreat, Bethesda, MD

Feb, 2017

"Lung Development, Chronic Lung Disease of Prematurity and Pulmonary Hypertension" 20th Annual Update in Pediatric & Congenital Cardiovascular Disease Conference, Orlando FL

Aug, 2017

"Early lung progenitor cell commitment redefines alveolar epithelial ontogeny", Gordon Conference: Lung Development, Injury, and Repair, New London, NH

May, 2018

"Specification of the Proximal-Distal Axis in Lung Epithelial Development", Session D87-To Each its Own: Single Cell mRNA Sequencing in Lung Development and Disease, American Thoracic Society 2018 International Conference, San Diego, CA

Jun, 2018

"Lung Development and Origins of PH Associated with Chronic Lung Disease of Prematurity", Pulmonary Hypertension Association 2018 International PH Conference and Scientific Sessions, Orlando, FL

Nov, 2018

"The developmental ontology, generation, and regeneration of the lung alveolus". Invited speaker for the Department of Molecular Medicine at Cornell University, Ithaca, NY

Feb, 2019

"Lung disease and pulmonary hypertension in the premature infant". Invited speaker at 22nd Annual Update in Pediatric & Congenital Cardiovascular Disease Conference, Huntington Beach, CA

Feb, 2019

"The failing myocardium in pulmonary hypertension". Invited speaker at 22nd Annual Update in Pediatric & Congenital Cardiovascular Disease Conference, Huntington Beach, CA

Aug, 2019

"Spatiotemporal lineage mapping to define molecular crossroads of heart versus lung mesodermal fate", Gordon Research Conference on Lung Development, Injury and Repair, Bates College, Lewiston, ME

Mar, 2020

"Pulmonary vascular development", 13th International Conference on Neonatal and Childhood Pulmonary Vascular Disease, San Francisco, CA

May, 2020

Spatiotemporal Lineage Mapping to Define Molecular Crossroads of Heart Versus Lung Mesodermal Fate,  2020 American Thoracic Society International Conference, C97 REGULATION OF LUNG PROGENITOR CELLS AND DIFFERENTIATION / Mini Symposium

May, 2020

Re-Initiation of Developmental Paradigms for Regeneration After Neonatal Lung Injury,  2020 American Thoracic Society International Conference, D97 STEM CELLS, LUNG REPAIR, AND DISEASE / Mini Symposium

Apr, 2021

"Leveraging Neonatal Alveolar Epithelial Plasticity in Lung Generation and Regeneration ", in Molecular Mechanisms Regulating Lung Development, Regeneration and Repair session, American Physiological Society Annual Meeting at Experimental Biology 2021

Jul, 2021

"The ex-premature infant with pulmonary vein stenosis", PVS Network webinar

Oct, 2021

"Pulmonary vein developmental biology", Pulmonary Vein Stenosis Symposium, Atlanta, GA

Organizing Roles in Scientific Meetings:

Mar, 2019

Moderator, Session II: "Management of subcutaneous prostacyclin", "How to handle long-term intravenous therapy in children", and "Implantable pumps for PAH-experience in young adults". Expert panel member, "The ideal trial with parenteral prostacyclin". Pediatric Pulmonary Hypertension Expert Meeting on Parenteral Prostacyclin in Pediatric Pulmonary Hypertension
Bratislava, Slovakia

May, 2020

Moderator, 2020 American Thoracic Society International Conference, STEM CELLS, LUNG REPAIR, AND DISEASE
Philadelphia, PA

Oct, 2021

Co-course director, 1st annual PVS Symposium
Atlanta, GA

Grants:

Current:

Cleavable multimeric prodrugs for treating pediatric pulmonary hypertension, Translational Research in Pediatric and Obstetric Pharmacology and Therapeutics (R21 Clinical Trial Optional), NHLBI/NIH, 1 R21 HL159562-01, 7/2021-6/2023 (Michael Chorny, PI: David Frank, Co-Investigator), $137,500/annual direct costs (Role in grant: co-PI, 6th percentile. Effort will be subsumed by K08 award.)

Doris Duke Charitable Foundation Clinician Scientist Development Award, Doris Duke Charitable Foundation , 7/2020-6/2023 (David Frank, PI), $150,000/annual direct costs, 10% effort (Role in grant: PI, Effort subsumed by K08)

Molecular Atlas of Lung Development Program (LungMAP) Phase 2 Research Centers (U01- Clinical Trial Not Allowed), NHLBI/NIH, RFA-HL-19-020, 10/2019-10/2023 (Edward E. Morrisey, PI), $600,000/annual direct costs (Role in grant: Co-I, effort subsumed by K08 award)

Macromolecular prodrug targeting of pulmonary vasculopathy in pulmonary hypertension, Cardiac Center at Children's Hospital of Philadelphia, 1/2019-12/2021 (David B. Frank , PI: Michael Chorney, Co-Investigator), $100,000/annual direct costs (Role in grant: co-PI, effort subsumed by K08 award)

K08 Mentored Clinical Scientist Research Career Development Award, NIH/NHLBI, 1/2018-12/2022 (David Frank, PI), $147,600/annual direct costs, 75% effort (Role in grant: PI)

Past:

Deriving pulmonary vascular fate from cardiac mesoderm, W.W. Smith Foundation Trust, 1/2019-12/2019 (David B. Frank , PI), $91,107/annual direct costs (Role in grant: PI, effort subsumed by K08 award)

Parker B. Francis Fellowship Program, Parker B. Francis Foundation, 7/2016-6/2019 (David B. Frank, PI), $50,000/annual direct costs (Role in grant: PI)

Cardiac Center Research Grant, Children's Hospital of Philadelphia, 7/2016-7/2017 (Rachel Hopper, PI: David Frank, Co-Investigator), $25,000/annual direct costs (Role in grant: Co-PI)

CHOP Pediatric Scholars Program, National Institutes of Health, 5K12HD043245-15, 4/2016-1/2018 (Joseph St. Geme III, PI), $100,000/annual direct costs, 75% effort (Role in grant: Trainee)

The Matthew and Michael Wojciechowski Pediatric PH Research & Mentoring Grant, Pulmonary Hypertension Association/American Thoracic Society, 1/2016-1/2018 (David Frank, PI), $50,000/annual direct costs (Role in grant: PI)

T32 Training in Molecular Therapeutics for Pediatric Cardiology, National Institutes of Health, 5T32HL007915-17, 10/2013-3/2016 (Robert J. Levy, PI), $65,000/annual direct costs, 100% effort (Role in grant: Trainee)

Bibliography:

Research Publications, peer reviewed (print or other media):

1. Parks W T, Frank D B, Huff C, Renfrew Haft C, Martin J, Meng X, de Caestecker M P, McNally J G, Reddi A, Taylor S I, Roberts A B, Wang T, Lechleider R J: Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases. The Journal of biological chemistry 276(22): 19332-9, Jun 2001.

2. Wurthner J U, Frank D B, Felici A, Green H M, Cao Z, Schneider M D, McNally J G, Lechleider R J, Roberts A B: Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone. The Journal of biological chemistry 276(22): 19495-502, Jun 2001.

3. Frank David B, Abtahi Amir, Yamaguchi D J, Manning Suzanne, Shyr Yu, Pozzi Ambra, Baldwin H Scott, Johnson Joyce E, de Caestecker Mark P: Bone morphogenetic protein 4 promotes pulmonary vascular remodeling in hypoxic pulmonary hypertension. Circulation research 97(5): 496-504, Sep 2005.

4. Frank David B, Lowery Jonathan, Anderson Lynda, Brink Monique, Reese Jeff, de Caestecker Mark: Increased susceptibility to hypoxic pulmonary hypertension in Bmpr2 mutant mice is associated with endothelial dysfunction in the pulmonary vasculature. American journal of physiology. Lung cellular and molecular physiology 294(1): L98-109, Jan 2008.

5. Anderson Lynda, Lowery Jonathan W, Frank David B, Novitskaya Tatiana, Jones Mark, Mortlock Douglas P, Chandler Ronald L, de Caestecker Mark P: Bmp2 and Bmp4 exert opposing effects in hypoxic pulmonary hypertension. American journal of physiology. Regulatory, integrative and comparative physiology 298(3): R833-42, Mar 2010. PMCID: PMC2838658

6. Miller J Davin, Benjamin John T, Kelly David R, Frank David B, Prince Lawrence S: Chorioamnionitis stimulates angiogenesis in saccular stage fetal lungs via CC chemokines. American journal of physiology. Lung cellular and molecular physiology 298(5): L637-45, May 2010. PMCID: PMC2867403

7. Kruithof Boudewijn P T, Fritz David T, Liu Yijun, Garsetti Diane E, Frank David B, Pregizer Steven K, Gaussin Vinciane, Mortlock Douglas P, Rogers Melissa B: An autonomous BMP2 regulatory element in mesenchymal cells. Journal of cellular biochemistry 112(2): 666-74, Feb 2011. PMCID: PMC4198144

8. Frank David B, Patel Akash R, Sanchez Guillermo R, Shah Maully J, Bonney William J: Junctional tachycardia in a child with Lyme carditis. Pediatric cardiology 32(5): 689-91, Jun 2011.

9. Lau Kelvin C, Frank David B, Hanna Brian D, Patel Akash R: Utility of electrocardiogram in the assessment and monitoring of pulmonary hypertension (idiopathic or secondary to pulmonary developmental abnormalities) in patients less than 18 years of age. The American journal of cardiology 114(2): 294-9, Jul 2014.

10. Frank David B, Crystal Matthew A, Morales David L S, Gerald Ken, Hanna Brian D, Mallory George B, Rossano Joseph W: Trends in pediatric pulmonary hypertension-related hospitalizations in the United States from 2000-2009. Pulmonary circulation 5(2): 339-48, Jun 2015. PMCID: PMC4449246

11. Peng Tien, Frank David B, Kadzik Rachel S, Morley Michael P, Rathi Komal S, Wang Tao, Zhou Su, Cheng Lan, Lu Min Min, Morrisey Edward E: Hedgehog actively maintains adult lung quiescence and regulates repair and regeneration. Nature 526(7574): 578-82, Oct 2015. PMCID: PMC4713039

12. Wang Yi, Frank David B, Morley Michael P, Zhou Su, Wang Xiaoru, Lu Min Min, Lazar Mitchell A, Morrisey Edward E: HDAC3-Dependent Epigenetic Pathway Controls Lung Alveolar Epithelial Cell Remodeling and Spreading via miR-17-92 and TGF-β Signaling Regulation. Developmental cell 36(3): 303-15, Feb 2016. PMCID: PMC4750387

13. Frank David B, Peng Tien, Zepp Jarod A, Snitow Melinda, Vincent Tiffaney L, Penkala Ian J, Cui Zheng, Herriges Michael J, Morley Michael P, Zhou Su, Lu Min Min, Morrisey Edward E: Emergence of a Wave of Wnt Signaling that Regulates Lung Alveologenesis by Controlling Epithelial Self-Renewal and Differentiation. Cell reports 17(9): 2312-2325, Nov 2016.

14. Zepp JA, Zacharias WJ, Frank DB, Cavanaugh CA, Zhou S, Morley MP, Morrisey EE: Distinct Mesenchymal Lineages and Niches Promote Epithelial Self-Renewal and Myofibrogenesis in the Lung. Cell 170(6): 1134-1148, Sep 2017.

15. Goddard LM, Duchemin AL, Ramalingan H, Wu B, Chen M, Bamezai S, Yang J, Li L, Morley MP, Wang T, Scherrer-Crosbie M, Frank DB, Engleka KA, Jameson SC, Morrisey EE, Carroll TJ, Zhou B, Vermot J, Kahn ML: Hemodynamic Forces Sculpt Developing Heart Valves through a KLF2-WNT9B Paracrine Signaling Axis. Developmental Cell 43(3): 274-89, November 2017.

16. Swarr DT, Peranteau WH, Pogoriler J, Frank DB, Adzick NS, Hedrick HL, Morley M, Zhou S, Morrisey EE: Novel Molecular and Phenotypic Insights into Congenital Lung Malformations. Am J Respir Crit Care Med January 2018.

17. Zacharias WJ*, Frank DB*, Zepp JA, Morley MP, Alkhaleel FA, Kong J, Zhou S, Cantu E, Morrisey EE.: Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor. Nature 555(7695): 251-255, February 2018.

18. Sivakumar, A., Mahadeven A., Lauer, M.E., Narvaez, R.J., Ramesh, S., Demler, C.M., Souchet, N.R., Hascall, V.C., Midura, R.J., Garantziotis, S., Frank D.B., Kimata, K., Kurpios, N.A. : Midgut laterality is driven by hyaluronan on the right. Developmental Cell 46(5): 533-551, September 2018.

19. Adang, L.A.*, Frank, D.B.*, Gilani, A., Takanohashi, A., Ulrick, N., Collins, A., Cross, Z., Galambos, C. Helman, G., Kanaan, U., Keller, S., Simon, D., Sherbini, O, Hanna, B.D., Vanderver, A.L. : Aicardi Goutieres Syndrome is associated with pulmonary hypertension. Mol Genet Metab 125(4): 351-358, December 2018.

20. Frank D.B., Penkala, I.J., Sivakumar, A., Linares, R.A., Zepp J.A., Zacharias W.J., Stolz, K.G., Pankin, J., Lu, M.Q., Wang, Q., Babu, A., Zhou, S., Li, L., Morley, M.P., Jain, R., Morrisey, E.E.: Early lineage specification defines alveolar epithelial ontogeny in the lung. PNAS Page: doi: 10.1073, February 2019 Notes: epub ahead of print.

21. Edwards JJ, Murali C, Pogoriler J, Frank DB, Handler SS, Deardorff MA, Hopper RK: Histopathologic and Genetic Features of Alveolar Capillary Dysplasia with Atypical Late Presentation and Prolonged Survival. Journal of Pediatrics 210(1): 214-219, July 2019.

22. Ikonomou L, Herriges MJ, Lewandowski SL, Marsland R 3rd, Villacorta-Martin C, Caballero IS, Frank DB, Sanghrajka RM, Dame K, Kańduła MM, Hicks-Berthet J, Lawton ML, Christodoulou C, Fabian AJ, Kolaczyk E, Varelas X, Morrisey EE, Shannon JM, Mehta P, Kotton DN: The in vivo genetic program of murine primordial lung epithelial progenitors. Nat Commun 11(1): 635, January 2020. PMCID: PMC6994558

23. Vanderver A, Adang L, Gavazzi F, McDonald K, Helman G, Frank DB, Jaffe N, Yum SW, Collins A, Keller SR, Lebon P, Meritet JF, Rhee J, Takanohashi A, Armangue T, Ulrick N, Sherbini O, Koh J, Peer K, Besnier C, Scher C, Boyle K, Dubbs H, Kramer-Golinkoff J, Pizzino A, Woidill S, Shults J: Janus Kinase Inhibition in the Aicardi-Goutières Syndrome. N Engl J Med 383(10): 986-989, Sep 2020.

24. Michael L. O'Byrne, Jennifer A. Faerber, Hannah Katcoff, David B. Frank, Alex Davidson, Therese M. Giglia, Catherine M. Avitabile: Variation in the use of pulmonary vasodilators in children and adolescents with pulmonary hypertension: a study using data from the MarketScan® insurance claims database. Pulmonary Circulation 10(3), October 2020.

25. Paris AJ, Hayer KE, Oved JH, Avgousti DC, Toulmin SA, Zepp JA, Zacharias WJ, Katzen JB, Basil MC, Kremp MM, Slamowitz AR, Jayachandran S, Sivakumar A, Dai N, Wang P, Frank DB, Eisenlohr LC, Cantu E 3rd, Beers MF, Weitzman MD, Morrisey EE, Worthen GS: STAT3-BDNF-TrkB signalling promotes alveolar epithelial regeneration after lung injury. Nat Cell Biol 22(10): 1197-1210, Oct 2020.

26. Catherine M Avitabile, Yan Wang, Xuemei Zhang, Heather Griffin , Sofia Saavedra, Samantha Adams, Lisa Herkert, David B Frank, Michael D Quartermain , Natalie E Rintoul , Holly L Hedrick, Laura Mercer-Rosa : Right Heart Strain, Brain Natriuretic Peptide, and Mortality in Congenital Diaphragmatic Hernia. Annals of the American Thoracic Society 17(11): 1431-1439, November 2020. PMCID: PMC7640722

27. Obraztsova K, Basil MC, Rue R, Sivakumar A, Lin SM, Mukhitov AR, Gritsiuta AI, Evans JF, Kopp M, Katzen J, Robichaud A, Atochina-Vasserman EN, Li S, Carl J, Babu A, Morley MP, Cantu E, Beers MF, Frank DB, Morrisey EE, Krymskaya VP.: mTORC1 activation in lung mesenchyme drives sex- and age-dependent pulmonary structure and function decline. Nat Commun 11(1): 5640, Nov 2020.

28. Zepp JA, Morley MP, Loebel C, Kremp MM, Chaudhry FN, Basil MC, Leach JP, Liberti DC, Niethamer TK, Ying Y, Jayachandran S, Babu A, Zhou S, Frank DB, Burdick JA, Morrisey EE.: Genomic, epigenomic, and biophysical cues controlling the emergence of the lung alveolus. Science 371(6534), March 2021. PMCID:  PMC8320017

29. Shah PP, Lv W, Rhoades JH, Poleshko A, Abbey D, Caporizzo MA, Linares-Saldana R, Heffler JG, Sayed N, Thomas D, Wang Q, Stanton LJ, Bedi K, Morley MP, Cappola TP, Owens AT, Margulies KB, Frank DB, Wu JC, Rader DJ, Yang W, Prosser BL, Musunuru K, Jain R.: Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes. Cell Stem Cell 28(5): 938-954, May 2021. PMCID: PMC8106635

30. Bose SK, White BM, Kashyap MV, Dave A, De Bie FR, Li H, Singh K, Menon P, Wang T, Teerdhala S, Swaminathan V, Hartman HA, Jayachandran S, Chandrasekaran P, Musunuru K, Jain R, Frank DB, Zoltick P, Peranteau WH: In utero adenine base editing corrects multi-organ pathology in a lethal lysosomal storage disease. Nat Commun 12(1), July 2021. PMCID: PMC8277817

31. Chandrasekaran P, Kwok B, Han B, Adams SM, Wang C, Chery DR, Mauck RL, Dyment NA, Lu XL, Frank DB, Koyama E, Birk DE, Han L.:  Type V collagen regulates the structure and biomechanics of TMJ condylar cartilage: A fibrous-hyaline hybrid. Matrix Biol. 102: 1-19, August 2021. PMCID: PMC8549065

32. Penkala IJ, Liberti DC, Pankin J, Sivakumar A, Kremp MM, Jayachandran S, Katzen J, Leach JP, Windmueller R, Stolz K, Morley MP, Babu A, Zhou S, Frank DB*, Morrisey EE*: Age-dependent alveolar epithelial plasticity orchestrates lung homeostasis and regeneration. Cell Stem Cell 28(10): 1775-1789, October 2021. PMCID: PMC8500919

Research Publications, peer-reviewed reviews:

1. Frank D B, Hanna B D: Pulmonary arterial hypertension associated with congenital heart disease and Eisenmenger syndrome: current practice in pediatrics. Minerva pediatrica 67(2): 169-85, Apr 2015. PMCID: PMC4382100

2. Lori A.Christ, Jennifer M.Sucre, David B.Frank: Lung disease and pulmonary hypertension in the premature infant. Progress in Pediatric Cardiology Page: doi.org/10.1016, July 2019 Notes: epub ahead of print.

3. Aravind Sivakumar, David B. Frank: Paradigms That Define Lung Epithelial Progenitor Cell Fate in Development and Regeneration. Current Stem Cell Reports 5: 133-144, December 2019.

4. Frank DB, Levy PT, Stiver CA, Boe BA, Baird CW, Callahan RM, Smith CV, Vanderlaan RD, Backes CH.: Primary pulmonary vein stenosis during infancy: state of the art review. Journal of Perinatology 41(7): 1528-1539, July 2021.

Abstracts:

1. Frank David, Johnson Joyce, de Caestecker Mark: Bone morphogenetic protein 4 promotes vascular remodeling in hypoxic pulmonary hypertension. Chest 128(6 Suppl): 590S-591S, Dec 2005.

2. David B. Frank, Raj Jain, Ian A. Penkala, Katharine G. Stolz, Josh Pankin, Michael Morley, Su Zhou, Min Min Lu, Edward E. Morrisey: Transcriptional repressive and activation programs regulate alveolar epithelial cell fate and plasticity for lung alveolar generation. Poster-Pulmonary Vascular Research Institute Annual World Conference, Miami, FL January 2017.

3. David B. Frank, Raj Jain, Ian A. Penkala, Katharine G. Stolz, Josh Pankin, Michael Morley, Su Zhou, Min Min Lu, Edward E. Morrisey: Early lung progenitor cell commitment redefines alveolar epithelialontogeny. Podium-Gordon Research Conference on Lung Development, Injury, and Repair, New London, NH August 2017.

4. Ian Penkala, David B. Frank, Rajan Jain, Katharine G. Stolz, Edward E. Morrisey: Temporal and transcriptional control of alveolar epithelial cell fate and plasticity during development. Poster-Gordon Research Conference on Lung Development, Injury, and Repair, New London, NH August 2017.

5. William Zacharias, MD PhD, David Frank MD PhD, Jarod Zepp PhD, Ed Cantu MD, Farrah Alkahleel, Michael Morley MS, and Ed Morrisey PhD: Wnt responsiveness and expression of Tm4sf1 mark a novel alveolar stem cell population which expands after injury to regenerate the alveolar epithelium in mouse and human lung. Poster-Gordon Research Conference on Lung Development, Injury, and Repair, New London, NH August 2017.

6. David B. Frank, Ian A. Penkala, Jarod A. Zepp, William J. Zacharias, Katharine G. Stolz, Josh Pankin, MinQi Lu, Qiaohong Wang, Apoorva Babu, Li Li, Su Zhou, Michael P. Morley, Rajan Jain, Edward E. Morrisey: Early lineage specification defines alveolar epithelial ontogeny in the lung. Poster-FASEB Conference, Lung Epithelium in Health and Disease, Olean, NY August 2018.

7. Aravind Sivakumar, Derek Liberti, Jarod Zepp, Josh Pankin, MinQi Lu, Michael Morley, Apoorva Babu, Edward E Morrisey, David B Frank: Mechanisms regulating pulmonary arterial morphogenesis during development and disease. Poster-University of Pennsylvania 25th Annual Respiratory Research Retreat, Philadelphia, PA May 2019.

8. Josh Pankin, MinQi Lu, Michael Morley, Apoorva Babu, David B Frank: Spatiotemporal lineage mapping to define molecular crossroads of heart versus lung mesodermal fate. Podium-Gordon Research Conference on Lung Development, Injury and Repair, Bates College, Lewiston, ME August 2019.

9. Vanderver A, Adang L, Gavazzi F, Ulrick N, Koh J, McDonald K, Peer K, Besnier C, Cross Z, Frank D, Helman G, Jaffe N, Kramer-Golinkoff J, Pizzino A, Rand E, Rhee J, Waldman A, Woidill S, Yum S,  Takanohashi A, Armangue T, Goldbach Mansky R, Shults J: Open label use of the Janus kinase inhibitor baricitinib in a genetic interferonopathy, Aicardi Goutières Syndrome. Podium-48th Annual Meeting of the Child Neurology Society, Charlotte, NC October 2019.

10. Michael L O'Byrne, Jennifer A Faerber,  Hannah Katcoff, , David B Frank, Alex Davidson, Therese M Giglia, Catherine M Avitabile: Variation in utilization of pulmonary vasodilators in children and adolescents with pulmonary hypertension:  An analysis of data from the Marketscan® Commercial and Medicaid Claims Databases Poster-American Heart Association Scientific Sessions, Philadelphia, PA November 2019.

11. A. Naik, Y. Issah, K. Forrest, D. B. Frank, A. Paris, A. Vaughan, S. Sengupta: Role of Circadian Clock in Lung Repair and Regeneration. American Thoracic Society International Conference Abstracts > C62. EPITHELIUM, INJURY, AND REPAIR May 2020.

12. D. B. Frank, K. Quansah, S. Jayachandran, M. Lu, J. Pankin, A. Sivakumar: Spatiotemporal Lineage Mapping to Define Molecular Crossroads of Heart Versus Lung Mesodermal Fate. American Journal of Respiratory and Critical Care Medicine 2020 201(A5985), May 2020.

13. D. B. Frank, S. Jayachandran, A. Sivakumar, M. Lu, K. Quansah, J. Pankin: Re-Initiation of Developmental Paradigms for Regeneration After Neonatal Lung Injury. American Journal of Respiratory and Critical Care Medicine 2020 201(A7679), May 2020.

Editorials, Reviews, Chapters, including participation in committee reports (print or other media):

1. David B. Frank, Edward E. Morrisey: Hedgehog and WNT Signaling: Signaling Hubs in Tracheal Morphogenesis. American Journal of Respiratory and Critical Care Medicine Page: doi: 10.1164, July 2019 Notes: Epub ahead of print.