Gerard A Lutty, PhD
Disclosures: Nothing to disclose
BIOSKETCH

Gerard A. Lutty, Ph.D.

 

BIOSKETCH

 

Gerard Lutty, Ph.D., received his BS in Zoology (1970) and MS in Microbiology (1980) from Catholic University in Washington, D.C., and his Ph.D. in Cell Biology at Johns Hopkins School of Medicine (1991). He has been a faculty member at Johns Hopkins since 1979 and is currently the inaugural G. Edward and G. Britton Durell Professor of Ophthalmology.  He was awarded the Endre Balazs Prize by ISER for excellence in ophthalmic  research in 2012.

              Dr. Lutty has demonstrated the mechanisms by which the retinal and choroidal vasculatures develop. He has studied the vaso-obliteration that occurs in oxygen-induced retinopathy (OIR) and the angiogenic processes that follow.  He has used this model to demonstrate the dangers of anti-VEGF agents in treating OIR but also shown how proper dose and timing of administration can result in complete inhibition of pathological neovascularization and permit normal retinal vascular development. He is currently using this model to development non-viral gene therapies employing nanoparticles.

He has contributed substantially to our understanding of vaso-occlusive and vasoproliferative stages of sickle cell and diabetic retinopathies. He has visualized and quantified the degeneration of RPE and choriocapillaris age-related macular degeneration (AMD) and demonstrated that three endogenous anti-angiogenic factors are reduced or missing in the RPE/Bruch’s membrane/choriocapillaris complex in AMD, making this environment permissive for choroidal neovascularization. His recent work focuses on the role of choroidal mast cells in AMD.

 

 

 

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